Wiegman confirmed Chelsea midfielder Keira Walsh is captain for the game at Etihad Stadium (17:30 BST) in Leah Williamson’s absence, with the Arsenal defender yet to play this season following knee surgery.
Walsh, 28, is a lifelong Manchester City fan and spent eight years at the club before completing a then world record move to Barcelona in 2022.
“It’s a role Keira massively deserves. It’s someone who probably doesn’t give herself enough credit in the leadership role but she is super influential,” said Greenwood.
“I’m a touch older than Keira and she’s a really good friend of mine but she impacts this team so much more than she even knows – on and off the pitch.
“It’s her experience and demands of high quality, day-in-day-out.”
It will also be a “really special” night for Greenwood, who is the Manchester City captain and has never played at Etihad Stadium with England.
“In a sense, it’s like going home,” she said. “It will be something I’ll cherish for a long time. The last time we played in Manchester was at Euro 2022 (at Old Trafford) so it’s been a while but this time I get to do it on my side which is really nice.”
The game against Brazil also marks the start of a new cycle for England as they prepare for the 2027 Women’s World Cup.
There are new players in the squad including uncapped Aston Villa midfielder Lucia Kendall, Arsenal defender Taylor Hinds and Liverpool captain Grace Fisk.
There has also been change in the coaching staff with Wiegman’s former right-hand man Arjan Veurink joining the Netherlands as head coach and Janneke Bijl and Arvid Smit coming the other way to the Lionesses as assistant coaches.
“I think it’s important to see it as a new cycle but we won’t be starting fresh. We will continue where we left off,” said Greenwood.
“While we have got new faces in the player and staff group, it’s important we don’t put what we’ve done to bed and we build on that – add rather than take away.
“The sessions have been really fun. It’s really nice to have fresh ideas. It’s helpful and it progresses us all.”